TRIM28 as a novel transcriptional elongation factor
نویسندگان
چکیده
منابع مشابه
Elongation factor P mediates a novel post-transcriptional regulatory pathway critical for bacterial virulence.
Bacterial pathogens detect and integrate multiple environmental signals to coordinate appropriate changes in gene expression including the selective expression of virulence factors, changes to metabolism and the activation of stress response systems. Mutations that abolish the ability of the pathogen to respond to external cues are typically attenuating. Here we discuss our recent discovery of ...
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A chemical kinetic model of the elongation dynamics of RNA polymerase along a DNA sequence is introduced. The proposed model governs the discrete movement of the RNA polymerase along a DNA template, with no consideration given to elastic effects. The model’s novel concept is a “look-ahead” feature, in which nucleotides bind reversibly to the DNA prior to being incorporated covalently into the n...
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ژورنال
عنوان ژورنال: BMC Molecular Biology
سال: 2015
ISSN: 1471-2199
DOI: 10.1186/s12867-015-0040-x